Events Calendar
DSAS Colloquium - Christoph Frei
November 15, 2018
Applied Math Colloquium
November 16, 2018
DSAS - Department Meeting
November 22, 2018
DSAS Colloquium
November 22, 2018

School of Mathematical & Statistical Sciences Colloquium

Date:
Wednesday, September 26, 2018
Time:
2:30 pm
Location:
North Campus Building (NCB)
Room: 114
Cost:
Free

Title: Modeling and Simulation for Drug Development
Speaker: Anita T. Layton


Canada 150 Research Chair in Mathematical Biology and Medicine
Professor of Applied Mathematics and Pharmacy, University of Waterloo


Computational modeling can be used to reveal insights into the mechanisms and potential side effects of a new drug. Here we will focus on two major diseases: diabetes, which affects 1 in 10 people in North America, and hypertension, which affects 1 in 3 adults.
For diabetes, we are interested in a class of relatively novel drug treatment, the SGLT2 inhibitors (sodium-glucose co-transporter 2 inhibitors). E.g., Dapagliflozin, Canagliflozin, and Empagliflozin. We conduct simulations to better understand any side effect these drugs may have on our kidneys (which are the targets of SGLT2 inhibitors). Interestingly, these drugs may have both positive and negative side effects.
For hypertension, we want to better understand the sex differences in the efficacy of some of the drug treatments. Women generally respond better to ARBs (angiotensin receptor blockers) than ACE inhibitors (angiontensin converting enzyme inhibitors), whereas the opposite is true for men. We have developed the first sex-specific computational model of blood pressure regulation, and applied that model to assess whether the "one-size-fits-all" approach to blood pressure control is appropriate
with regards to sex.

Contact:
Rick Jardine
jardine@uwo.ca
Event Type:


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