Events Calendar

Magnetothermal Deep-Brain Neuromodulation..., A. Pralle

Date:
Thursday, March 8, 2018
Time:
1:30 pm - 2:30 pm
Location:
Physics & Astronomy Building (PAB)
Room: 100
Cost:
Free

Department of Physics and Astronomy

PHYSICS & ASTRONOMY COLLOQUIUM

Dr. Arnd Pralle

Department of Physics
University at Buffalo, SUNY

“Magnetothermal Deep-Brain Neuromodulation in Freely Behaving Mice”

ABSTRACT

Establishing how neurocircuit activation causes particular behaviors requires modulating the activity of specific neurons. I will demonstrate that magnetothermal genetic stimulation provides tetherless deep brain activation sufficient to evoke motor behavior in awake mice. The approach uses alternating magnetic fields to heat superparamagnetic nanoparticles on the neuronal membrane. Neurons, heat-sensitized by expressing TRPV1 are activated with magnetic field application. Magnetothermal genetic stimulation in the motor cortex evoked ambulation, deep brain stimulation in the striatum caused rotation around the body-axis, and stimulation near the ridge between ventral and dorsal striatum caused freezing-of-gait. The duration of the behavior correlated tightly with field application. This approach provides genetically and spatially targetable, repeatable and temporarily precise activation of deep-brain circuits without the need for surgical implantation of any device.

STUDENTS – after the talk, you’re encouraged to return to the 2nd floor Atrium lounge to meet with the speaker. 
COFFEE – coffee and cookies will be available in the 2nd floor Atrium lounge at 1:15 p.m.
CELL PHONES – as a courtesy to the speaker and audience, please set your cellphones to “silent” mode. Thanks!
Host:
Prof. A. Soddu
Contact:
Jodi Guthrie - Assistant to the Chair
jodi@uwo.ca
519-661-2111 ext. 86438
Event Type:


Powered by Blackbaud
nonprofit software