Events Calendar

Visiting Speaker in Chemistry ~ Prof. Jean-Paul Desaulniers

Date:
Wednesday, April 19, 2017
Time:
10:30 am - 11:30 am
Location:
Chemistry Building (CHB)
Room: 115
Cost:
Free

Professor Jean-Paul Desaulniers
Faculty of Science
University of Ontario Institute of Technology

 will present a talk entitled:

 “Chemically -Modif ied siRNAs that Make Sense ”

ABSTRACT:
Aberrant gene expression is a hallmark of disease and targeting messenger RNA through RNA interference is a promising approach to reduce the expression of deleterious proteins.  However, some of the current problems associated with using oligonucleotides as therapeutics include off‐target toxicity, chemical lability, and poor cellular delivery.   Many  of  these  challenges  are  attributed  to  the  native  negatively  charged phosphodiester backbone of the oligonucleotide. As such, our current interest in overcoming these obstacles involves chemical modification of the backbone with neutral unnatural functional groups. In particular, we have interest in designing and modifying siRNAs bearing non-natural aromatic functionalities.1-4   This talk will focus on many of the types of chemical modifications that our group has been working on over the last few years that are compatible within the RNAi machinery.   This development will allow for future chemical investigations that are compatible within the RNAi pathway.

 

  1. T.C. Efthymiou, V. Huynh, J. Oentoro, B. Peel, and J.-P. Desaulniers. "Efficient Synthesis and Cell-Based Silencing Activity of siRNAs that Contain Triazole Backbone Linkages" Bioorg. Med. Chem. Lett. 2012, 22, 1722-1726.
  2. B. J. Peel, G. Hagen, K. Krishnamurthy, and J.-P. Desaulniers. "Conjugation and Evaluation of Small Hydrophobic Molecules to Triazole-Linked siRNAs" ACS Med. Chem. Lett. 2015, 6, 117-122.
  3. G. Hagen, B. J. Peel, J. Samis, and J.-P. Desaulniers. "Synthesis and Biological Assessment of Chemically Modified siRNAs Containing 2'-Ribose Modifications with Triazole-Linked Backbone Modifications" MedChemComm, 2015, 6, 1210-1215.
  4. J.-P. Desaulniers, G. Hagen, J. Anderson, C. McKim, and B. Roberts. "Effective Gene-Silencing of siRNAs that Contain Functionalized Spacer Linkages Within the Central Region" RSC Advances 2017, 7, 3450-3454.
Host:
Department of Chemistry
Contact:
Robert H.E. Hudson - Professor
rhhudson@uwo.ca
X86349
Event Type:


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